PLATELET-DERIVED
GROWTH FACTOR RECEPTOR
BETA (PDGF Rβ)
GENE EXPRESSION
OVERVIEW EXPLANATION
This assay identifies the presence of a substance, PDGF Rβ, that fights against the natural destruction process for cells, known as Apoptosis. Elevated quantities indicate that there is an increased number of transformed cells that are not being destroyed. Simultaneously such a situation will accelerate any wound healing whilst slow wound healing is associated with low quantities.
DETAILED EXPLANATION
PDGF Rβ is expressed on the endothelial, stromal and mesangial cells and may be over-expressed on some tumour cells. When it binds its ligand (PDGF) a number of processes are stimulated within a cell including the generation of the anti-apoptotic (anti-destructive) signal. This assay is designed to evaluate the presence of one of the main factors that contributes to the resistance of a cell containing the factor to be destroyed (Apoptosis).
High PDGF Rβ quantities are associated with an inhibition of the destruction of cells containing PDGF Rβ, in particular if there is platelets aggregation as this will protect transformed cells from destruction. It will also accelerate wound healing if there is a need. Low quantities indicate a risk of slow wound healing.
APPLICATION
This assay will provide extremely valuable and accurate information relating to all forms of cancer.
This assay identifies the presence of a substance, PDGF Rβ, that fights against the natural destruction process for cells, known as Apoptosis. Elevated quantities indicate that there is an increased number of transformed cells that are not being destroyed. Simultaneously such a situation will accelerate any wound healing whilst slow wound healing is associated with low quantities.
DETAILED EXPLANATION
PDGF Rβ is expressed on the endothelial, stromal and mesangial cells and may be over-expressed on some tumour cells. When it binds its ligand (PDGF) a number of processes are stimulated within a cell including the generation of the anti-apoptotic (anti-destructive) signal. This assay is designed to evaluate the presence of one of the main factors that contributes to the resistance of a cell containing the factor to be destroyed (Apoptosis).
High PDGF Rβ quantities are associated with an inhibition of the destruction of cells containing PDGF Rβ, in particular if there is platelets aggregation as this will protect transformed cells from destruction. It will also accelerate wound healing if there is a need. Low quantities indicate a risk of slow wound healing.
APPLICATION
This assay will provide extremely valuable and accurate information relating to all forms of cancer.
