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VASCULAR ENDOTHELIAL
GROWTH FACTOR (VEGF)
GENE EXPRESSION

OVERVIEW EXPLANATION

VEGF is a key factor in the process of angiogenesis, the formation of new blood vessels. Regular blood vessel formation is a normal and necessary part of growth and development, one that is increased when additional oxygen and nutrients are needed, as when the body seeks to heal itself of a wound or other physical trauma, and during pregnancy. However, excessive concentrations of VEGF suggest that Cancer Cells are also being “fed” via blood vessel distribution channels. As such, high quantities of the VEGF protein are considered a risk factor for tumour growth. The converse situation, when VEGF quantities are found to be lower than normal, can lead to the development of cardiovascular problems due to a decreased supply of nutrients and oxygen to healthy cells.

DETAILED EXPLANATION

VEGF is a key factor in angiogenesis (i.e. the neovascularisation or the formation of new blood vessels). This assay is able to assist in the estimation of the risk factor that is able to suppress the host anti-tumour immune response and stimulate tumour growth.

High quantities can be associated with tumour growth due to an increased supply of nutrients and oxygen to the transformed cells. Low quantities may result in cardio-vascular problems due to a decreased supply of nutrients and oxygen to the normal cells. The processes of wound healing (i.e. after an operation or experiencing physical trauma) or pregnancy are accompanied by elevated VEGF quantities.

APPLICATION

This assay will provide extremely valuable and accurate information relating to the following pathological conditions :-

- Cancer, stroke, cardiovascular problems and infertility.
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