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Targeted research into the properties of Neuropeptides during the last twenty years has resulted in a major review of previous conceptions. Comparison of differences between neurotransmitters and Neuropeptides indicate that :-

1. Although peptides are present in much smaller quantities they are very potent.

2. Some Neuropeptides found in the brain also appear in the gastro-intestinal system.

3. There is a possibility that some Neuropeptides may change their role when they appear in different locations.

4. There is evidence that shows that there is a strong possibility that some Neuropeptides are associated with Thyroid Problems and reduced mobility.


A neuropeptide is, in general terms, classified as a chain of amino acid molecules that is produced in the nervous system, particularly the brain.

In the past few years a great amount of information has become available about the properties of neuro-active peptides, primarily due to targeted research. Some of the findings have enhanced previous knowledge whilst others have completely changed previous conceptions.

The principle differences between Neuropeptides and neurotransmitters are that :-

1. Peptides are extremely potent.

2. The quantities of peptides present are much smaller than neurotransmitters.

3. Their mode of Synthesis is substantially different.

Many Neuropeptides that are found in the brain can also be found in the gastro-intestinal system. However, it has yet to be finally established whether they change their function when they change their location.

The compound somatostatin is just one of a group of peptides that was originally detected in the hypothalamus but is now known to have profound actions on the endocrine function of the pituitary gland. Many of these peptides have subsequently been found in the hypothalamus where they appear to have a function not dissimilar to that of a neurotransmitter.

There are indications, from recent research, that somatostatin could be acting as a neurotransmitter in the spinal chord. It is also known to influence the behavioural characteristics of individuals that suggest that it can act as a depressant and suppressor of thyroid hormones release, as well as being associated with reduced motor activity.

Overall there is a very strong case that the full range of neuropeptide levels need to be included as part of any investigation into the following conditions :-

1. Suspected thyroid malfunctioning whether it be at an increased or decreased level of thyroid hormones.

2. Behavioural problems and abnormalities.

3. Stress or depression.


This assay will provide invaluable information relating to some 26 Neuropeptides. These Neuropeptides are categorised into some 12 sub-groups and amongst these groups are the following :-

- Regulators of immunological activity, regulators of pancreatic activity, regulators of growth hormone release, regulators of gastro-intestinal activity conductors and suppressors of pain, regulators of moods and the poor co-ordinator of motor activity.

This assay is particularly useful when the patient is suffering from all forms of cancer, Diabetes, Thyroid Problems, memory and learning difficulties, kidney problems, gastro-intestinal problems, depression or behavioural problems.


1. Emson, P. C. (1979). Peptides as neurotransmitter candidates in the CNS. Prog. Neurobiol., 13: 61-116.

2. Iversen, L. L., Nicol, R. A. and Vale, W. W. (1978). Neurobiology of Peptides. Neuroscience Res. Program Bull, 16(2): 211-370.

3. Kolb, B., Whishaw, I. Q. (1990). Fundamentals of Human Neuropsychology, 3rd Edition.

4. Krieger, D. T., Browstein, M. J. and Martins, J. B. (1983). Brain Peptides. Wiley, New York.
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