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/CD156B (TACE/ADAM 17)


TNF-α converting Enzyme is responsible for the discarding of receptors that are located on the surface of cells. Any shed receptors bind to a receptor and have a natural anti-tumour effect. Elevated quantities are a positive indicator for patients suffering from cancer whilst low quantities require enhancement.


TACE/ADAM 17 is an active protease which belongs to the adamalysin family and is encoded by
the TACE/ADAM 17 gene. This Enzyme is secreted by some immunological cells such as monocytes, macrophages and granulocytes. TACE/ADAM 17 plays an essential role in the shedding of number receptors (EGF R, p185, etc.) located on the cell surface. Many types of receptors located on the transformed cells and promoting the growth of their population could be shedded. Shedded soluble receptors have a natural anti-tumour effect by binding the ligand to the receptor. Therefore the ligand is not able to induce the signal for growth through the unshedded receptor on the cell surface.


This assay will provide extremely valuable and accurate information relating to all forms of cancer.
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