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As a member of the IL-1 family of Inflammation-inducing Cytokines, IL-33 (a signalling protein) is involved specifically in triggering the body’s “allergic reaction” to these substances. An assay for IL-33 can provide information on an individual’s level of allergenic sensitivity. High quantities indicate an imminent and elevated risk of potentially harmful asthma symptoms and low levels reflect the absence of such concerns.


IL-33 is a Cytokine produced mainly by the macrophages in response to allergens. This Cytokine is classified as a member of the interleukin 1 (IL-1) family which triggers inflammatory processes. IL-33 promotes the production of type 2 helper T cells (TM2) - associated Cytokines. This assay is able to provide information relating to the activation of the macrophages and, also, is designed to estimate the risk of allergic Inflammation in asthma.

High levels are associated with the imminent manifestation of allergic Inflammation in asthma which can lead to severe damage of the mucosa. Low levels of IL-33 are associated with the absence of a risk of developing allergic Inflammation in asthma, probably due to the absence of the appropriate allergen.


This assay will provide extremely valuable and accurate information relating to the following pathological condition :-

- Allergy.
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