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(IL-1α) GENE


IL-1α is a Cytokine (signalling protein) that is produced as part of the immune response to a bacterial infection. Some Cancer Cells can also produce IL-1α as part of a process that triggers increased body temperature (fever). Presence of the protein in high concentrations may reflect excessive Inflammation or problems in the liver and pancreatic function, while low quantities can indicate a diminished immune capacity. In cases of cancer, elevated quantities of IL-1α may indicate liver Metastasis.


IL-1a is a Cytokine produced mainly by the monocytes and the macrophages in response to a bacterial infection. Some cancerous cells are also able to produce IL-1a which, together with IL-1α, is the main endogenous pyrogen. Its pyrogenic action is due to increased production of the pro-inflammatory prostaglandins. This assay is able to provide information relating to the activation of the macrophages and also is designed to estimate the risk of Inflammation, oxidative stress, degeneration of the liver and the pancreas, and also Metastasis in the liver in the case of a tumour.

High quantities are associated with Inflammation, disruption of the liver and the pancreas functioning and, in cases of cancer, a risk of Metastasis in the liver. Low quantities of IL-1α are associated with a decreased ability of the Immune System to generate an acute response aimed at mobilising the defence against any invading infectious species.


This assay will provide extremely valuable and accurate information relating to the following pathological conditions :-

- Cancer, infections and Diabetes.
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