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BCL2 Gene Expression

OVERVIEW EXPLANATION

Cells produce BCL-2 protein to protect themselves against Apoptosis (programmed cell death). Cancerous and virally infected cells can use this BCL-2 protective capacity to avoid their elimination by the bodyís immunological defence system, leading to further malignant growth.

The assay for BCL-2 clarifies the resistance levels of these Abnormal Cells to such programmed elimination. High BCL-2 quantities indicate that cancerous and infected cells are effectively resisting Apoptosis, while minimal quantities suggest the possibility of successfully targeting them for destruction. Particularly low BCL-2 quantities may also signify the inappropriate eradication of normal cells, including cells of the Immune System.

DETAILED EXPLANATION

BCL-2 protein is produced by a cell to defend itself against Apoptosis (programmed cell death) and, therefore BCL-2 has anti-apoptotic properties. Protein BCL-2 inhibits Apoptosis by preventing the release of the Apoptosis inducing factor (AIF) and the cytochrome C from mitochondria. BCL-2 regulates the outer mitochondrial membranes permeability. Many Cancer Cells over produce BCL-2 thus preventing Apoptosis and permitting further malignant growth. Increased BCL-2 in normal cells will prevent their destruction if a virus infects them. This could lead to a further accumulation of Abnormal Cells. This assay is able to provide information related to Apoptosis (programmed cell death) of cancer and Abnormal Cells and also ability of normal cells (including immunological cells) to resist the actions of destructive factors.

High quantities are associated with the resistance of Abnormal Cells (transformed and/or infected) to self-destruction. Very low quantities are associated with the possibility to induce Apoptosis, by various means, of cancer / infected cells. Also, very low quantities could be associated with a risk of self-destruction of the normal cells, including immunological cells.

APPLICATION

This assay will provide extremely valuable and accurate information relating to the following pathological conditions :-

- All forms of cancer, Multiple Sclerosis ( MS ) and Parkinsonís disease.
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