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The Cytokine (signalling protein) IL-12 plays an important role in the initiation and regulation of cellular immune responses, and in determining the type of resistance that will be activated in response to a particular infection. In excessive quantities, however, IL-12 can be involved in pathological conditions including Autism, multiple sclerosis, Auto-immune disease, and many bacterial and viral infections. Reduced quantities, on the other hand, indicate a diminished immune defence.


IL-12 is a Cytokine produced mainly by the macrophages, the dendritic cells and, to some extent, by the
B cells and it is needed to develop the normal immunological activity. The critical role of interleukin 12, in several pathologies, has been demonstrated in numerous clinical studies. Significant elevations have been discovered in autistic patients and sufferers of multiple sclerosis. Auto-immune diseases and chronic inflammatory reactions can all be accompanied by an increase in the quantity of IL-12. Additionally, a large number of bacterial and viral infections are capable of changing the expressed quantities of interleukin 12. This assay is able to assist in identifying the formation of the anti-tumour immunity and to provide information related to the presence of bacterial and viral infections. It is designed to estimate the interleukin 12 gene expression as part of the characterisation of the Th1/Th2 immunological balance.

Increased quantities are associated with active Th1 cellular (destructive) immunity in response to a bacterial infection or some form of treatment. Low quantities are associated with non-active Th1 immunity.


This assay will provide extremely valuable and accurate information relating to the following pathological conditions :-

- Cancer, rheumatoid arthritis and Inflammation.
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